www.BostonTestosterone.com

Hey guys, by now you all know I am a numbers and logic guy. (MIT, Yale Medical and Harvard University will do that)

Whatever I prescribe has to be justifiable and have scientific back-up. I wanted to make you aware of an important cause of fatigue, constipation, memory loss, numbness, that is not so uncommon these days.

Boston Testosterone Partners/Core New England provides Testosterone Replacement Therapy to men over 30 who suffer from low testosterone or andropause. Our patients also have access to cutting edge neutraceutical injectables.

Glutathione is perhaps the most exciting one of them all.

If you have not heard of glutathione yet, get ready, you will be.

Glutathione is referred to as the the mother of all antioxidants, the master detoxifier and maestro of the immune system. It’s the most important molecule you need to stay healthy and prevent disease yet you’ve probably never heard of it.

It’s the secret to prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer’s disease. The good news is that your body produces its own glutathione. The bad news is that poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete your glutathione. This leaves you susceptible to unrestrained cell disintegration from oxidative stress, free radicals, infections and cancer. And your liver gets overloaded and damaged, making it unable to do its job of detoxification.

What is Glutathione?

Glutathione is a very simple molecule that is produced naturally all the time in your body. It is a combination of three simple building blocks of protein or amino acids — cysteine, glycine and glutamine. The secret of its power is the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule. It acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals.

Normally glutathione is recycled in the body — except when the toxic load becomes too great. And that explains why we are in such trouble … The Importance of Glutathione in Protecting Against Chronic Illness.

Glutathione is critical for one simple reason : It recycles antioxidants. You see, dealing with free radicals is like handing off a hot potato. They get passed around from vitamin C to vitamin E to lipoic acid and then finally to glutathione which cools off the free radicals and recycles other antioxidants. After this happens, the body can “reduce” or regenerate another protective glutathione molecule and we are back in business.

However, problems occur when we are overwhelmed with too much oxidative stress or too many toxins. Then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can’t get rid of toxins. This leads to further sickness and soon we are in the downward spiral of chronic illness.

But that’s not all. Glutathione is also critical in helping your immune system do its job of fighting infections and preventing cancer. That’s why studies show that it can help in the treatment of AIDS.

Glutathione is also the most critical and integral part of your detoxification system. All the toxins stick onto glutathione , which then carries them into the bile and the stool — and out of your body.

And lastly, it also helps us reach peak mental and physical function. Research has shown that raised glutathione levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development. If you are sick or old or are just not in peak shape, you likely have glutathione deficiency. Keeping yourself healthy, boosting your performance, preventing disease and aging well depends on keeping your glutathione levels high. It is critical for immune function and controlling inflammation. It is the master detoxifier and the body’s main antioxidant, protecting our cells and making our energy metabolism run well.

Contact Boston Testosterone/Core New England today to find out how you can get started with Glutathione therapy today.

Boston Testosterone Partners/Core New England
“The Greatest Health of Your Life”℠
National Testosterone Restoration for Men
Wellness & Preventative Medicine
www.BostonTestosterone.com
cblaisdell@corenewenglandcom
855-617-MEDS (6337)/781-269-5953

Total testosterone will never tell you the entire story. Take our patients’ recent blood tests. He was first told by his Primary Care, “[Y]our fine, John. Your testosterone level is well within range. It’s just part of getting old. I can give you some Cialis.” Scratching his head, John left his primary care wondering how that could be. He suffered from all the ADAM subjective symptoms of low testosterone . He had read all about Testosterone Replacement on the internet and was sure that he was suffering from it.

So John, knowing his Primary Care Doctor must be wrong, sought out a second opinion with us. We immediately retested him, this time with the proper diagnostic panels included into his lab requisitions. Total, Free and Bioavailable testosterone . Based on his reported symptoms, we also included IGF-1 to see if he had some HGH deficiencies as well.

John came back with a severe deficiencies in both bioavailable testosterone and IGF-1 . (See the attached lab image showing in range total testosterone with deficiencies in bioavailable testosterone and IGF-1)

You see, what far too many Primary Care Doctors do not understand is that testosterone circulates in the blood in two forms – Free or Bound. Free testosterone is Bioavailable, meaning it is available for the cells to work with. However, bound testosterone is, essentially, bound to sex hormone binding globulin (“SHBG”) and is therefore blocked from acting in cells. When it is blocked, you cannot use it. When you cannot use it, you have Low T.

When you measure just Total Testosterone , you cannot make a proper diagnosis because you aren’t assessing the way a patient is using his circulating testosterone. It’s like a dentist saying all your teeth are fine by virtue of them all still being in your head. They always take a closer look at the teeth themselves.

So, albeit upset he had Low T, John was elated to get a proper diagnosis validating what he knew all along. We were also able to detect a severe IGF-1 deficiency that we were able to treat with our Sermorelin-GHRP2 Epi Pen protocols.

With balanced and optimized Testosterone and HGH levels, this patient was able to rid himself of all the symptoms he was suffering mightily from. Needless to say, John’s life has completely changed.

In conclusion, a man may have adequate total testosterone, but still suffer from the ravages of low testosterone levels if his bioavailable testosterone is low . If you are feeling the symptoms of Low T, don’t hesitate; seek out a qualified medical professional who specializes in hormone replacement.

“The Greatest Health of Your Life”℠

Boston Testosterone Partners/Core New England

National Testosterone Restoration for Men

Wellness & Preventative Medicine

www.BostonTestosterone.com

www.facebook.com/BostonTestosterone

cblaisdell@corenewengland.com

855-617-MEDS (6337)/781-269-5953

Testosterone replacement therapy for hypogonadal men has been used for decades. However, there are still scores of primary care doctors spreading irresponsible misinformation regarding the safety of this treatment, particularly to elderly men who can benefit mightily from a balanced hormonal health.

A study was done with 255 men with an Average age of 60.6 ± 8.0 years, with testosterone levels between ≤ 3.5 ng/ml. They received parenteral (injectable) testosterone undecanoate.

After more than five years of monitored testosterone therapy , the study noted that a mere 3 out of 255 patients were diagnosed with prostate cancer. The study stated that “3/255 patients with prostate cancer does not suggest an increased risk of prostate cancer in elderly men on long-term testosterone treatment. Long-term treatment with testosterone undecanoate with monitoring according to the guidelines is acceptably safe.”

Now, according to cancer.org, “About 1 man in 6 will be diagnosed with prostate cancer during his lifetime.” They also stated, “Prostate cancer can be a serious disease, but most men diagnosed with prostate cancer do not die from it. In fact, more than 2.5 million men in the United States who have been diagnosed with prostate cancer at some point are still alive today.”

In over 50 years of studies and research, there has never been a connection between testosterone levels in men and prostate cancer growth. Moreover, a study from Harvard Medical School in 2006 concluded, “there is not now, nor has there ever been a scientific basis for the belief that testosterone causes prostate cancer to grow.”

Just more evidence that testosterone replacement therapy does not cause cancer or prostate cancer. We can’t explain why leagues of completely clueless primary care doctors still spread baseless accusations that TRT is unsafe.

http://www.cancer.org/cancer/prostateca … statistics

Boston Testosterone is a Testosterone Replacement , Wellness and Preventative Medicine Medical Center that treats and prevents the signs and symptoms associated with Andropause and hormone imbalances. With affiliates nationally, Boston Testosterone offers hormone replacement therapy, weight loss protocols, erectile dysfunction (ED), Sermorelin-GHRP2 therapy and neutraceutical injectable therapies for men and women. Their medical facilities offer physician examinations and treatment programs that incorporate the latest in medical science.

“The Greatest Health of Your Life” ℠

Boston Testosterone Partners

www.BostonTestosterone.com

www.facebook.com/BostonTestosterone

855.617.MEDS (6337)/781-269-5953

CBlaisdell@corenewengland.com

See: Side-Effect Profile of Long-Term Treatment of Elderly Hypogonadal Men with Testosterone Undecanoate – Farid Saad, Ahmad Haider, Gheorghe Doros, Louis Gooren. Bayer Pharma AG, Berlin, Germany; Gulf Medical University School of Medicine, Ajman, United Arab Emirates; Private Practice, Bremerhaven, Germany; Public School of Health, Boston University, Boston, MA; VUMC Amsterdam, Amsterdam, Netherlands.

Yet another large study has found that testosterone replacement therapy is more likely to reduce than increase the risk of major adverse cardiac events. The new analysis was undertaken by researchers at the Intermountain Medical Center Heart Institute in Murray, Utah and presented at the 2014 scientific sessions of the American Heart Association.

Those researchers followed 5,695 men, all of them Intermountain patients between the ages of 53 and 71, who presented with low testosterone levels on blood tests. After at least 3 years of follow-up, men with persistently low testosterone levels had significantly higher rates of heart attack, stroke and related death than men who successfully used replacement therapy to achieve either normal or even high levels of testosterone.

Roughly 14% of the men in the low-testosterone group had used replacement therapy but failed to raise their levels into normal range. The rest opted against treatment. All of the men in the “normal” and “high” testosterone groups used replacement therapy throughout the study period. “Testosterone therapy has become very popular in the United States in recent years,” said Jeffrey Anderson, MD, a cardiologist at the Intermountain Medical Center Heart Institute, and lead researcher for the study. “With this study we are getting closer to defining the true associations between testosterone treatment and cardiovascular risks or benefits,” he said in a news release that accompanied presentation of the study results.

The new study is one of many to contradict a pair of much-publicized analyses that found significant associations between testosterone replacement and adverse cardiac events. The publication of those studies led public health advocates to demand the US Food and Drug Administration (FDA) review the safety data.

Almost immediately after they appeared, however, a steady stream of additional research began to undermine them, either by finding that testosterone replacement was not associated with any change to cardiovascular health or by finding that treatment was associated with fewer heart attacks and strokes.

The largest of these was an analysis of records from 25,420 Medicare beneficiaries, an analysis that found testosterone replacement to be associated with fewer myocardial infarctions (MIs) among men with the highest risk of heart disease and no significant change in MIs among other men.

The most dramatic study to associate testosterone replacement with fewer adverse cardiac events compared outcomes for 19,968 men who received therapy with general population data and found that men who received treatment faced far less than half the risk of either MI or stroke.

No other study has found any suggestion that testosterone therapy has such dramatic health benefits, but several others have found smaller, but still significant, positive associations between hormone replacement and heart health. That said, the FDA’s review did not find enough evidence to credibly tie testosterone replacement to any change, in either direction, in the risk of heart attack or stroke, so a pair of the agency’s advisory panels asked agency officials to force companies that sell testosterone to undertake definitive studies. Anderson, the lead author of the new study, also supports further studies but says his team’s work provides doctors with significant reason to believe that testosterone replacement is more likely to prevent than induce MI or stroke in hypogonadal men.

“While this study provides reassurance about the safety of using supplementation to move from low to normal levels of testosterone, more studies, particularly large randomized studies, are needed,” Anderson said. – See more at: http://www.hcplive.com/articles/Testosterone-Therapy-Does-Not-Increase-Risk-of-Heart-Attack-or-Stroke-in-Men-with-Hypogonadism#sthash.JTPHEJWj.dpuf By Andrew Smith December 16, 2014

Boston Testosterone Partners
BTP/CORE New England
Men’s Health Centers
920 Washington Street
Norwood, MA 02062
www.BostonTestosterone.com
781.269.5953

BTP/CORE Medical patient Robert, from the suburbs of Boston, sent this review in to us recently. At Boston Testosterone Partners/CORE Medical , we are very proud of our track record of helping thousands of men regain their zest and vigor for life.

Available Nationwide, call us at 855.617.6337 or visit us at www.bostontestosterone.com to get more information.

I am a 70 year old guy who has always been extremely active, bicycling 4000 to 5000 miles / year , hiking, skiing, and working out in the gym. Over the last few years, I have noticed a gradual drop in my athletic performance, slower recovery from exercise, and a loss of muscle mass. Even more distressingly, I had begun to have increasingly frequent incidents of erectile dysfunction. Given that my diet and exercise level was obviously not the issue and that I had no other health issues, these symptoms strongly suggested low testosterone. I decided to contact Core New England and Charlie Blaisdell. My initial blood work showed that I had the free testosterone of an 85 to 100 year old man.

Based on the results, and a discussion with ever helpful Charlie, I began testosterone replacement therapy with testosterone cypionate and anastrozole. As a scientist, I reviewed the available literature, which further confirmed the basis for each of these recommended prescriptions, and so I began treatment. My response was immediate. The following note is excerpted from an email that I sent to Charlie after two weeks on his recommended therapy:

I just wanted to give a quick update on my results so far (after two weeks). Athletically, I feel better than I have in several years. I am finding that when cycling I am in at least one gear higher with the same perceived effort. Last weekend, my wife and I cycled 45 miles over Brandon Gap and Middlebury Gap in Vermont. Ride was easy with no fatigue! I am waking up with morning wood, and the sexual issues are gone. I am getting results from my gym workouts now.

All in all, it is like a miracle!

Update after first ten weeks of therapy:

I continue to feel GREAT! My wife and I have been biking in Colorado and New Hampshire this summer, and I feel stronger that I have in 20 years! We did a 77 mile road bike loop through Pinkham Notch, Crawford Notch, routes 115 and 2 through Gorham and back to Pinkham two days ago and the ride was easier for me that it was when I last did it 10 years ago.

After three months:

The results continue to be amazing. On a recent strenuous hilly week of cycling in Italy, I had no problems keeping up with men 20 years younger than me, and in all ways I feel at least 20 to 30 years younger that before beginning testosterone replacement therapy. I have regained the muscle mass that I had lost over the last few years, and I recover from strenuous exertion in the way I did when I was much younger. Erectile dysfunction is a thing of the past.

Charlie is always available to for advice and to answer questions. If you suspect low testosterone, my advice is to contact Core New England and Charlie immediately. It can transform your life! It did mine!

By William Faloon

When we started offering comprehensive blood test panels, men did not understand why we were checking their estrogen levels. Back in those days, estrogen was considered a hormone of importance only to women.

We tested estrogen based on published data indicating that when estrogen levels are unbalanced, the risk of degenerative disease in aging men skyrockets.(1-7) Of concern to us 14 years ago were reports showing that excess estrogen contributes to the development of atherosclerosis.(8,9) Human clinical studies conducted more than a decade later confirmed our suspicions. Men with even slightly elevated estrogen levels doubled their risk of stroke and had far higher incidences of coronary artery disease.(10-12) Our early observations also revealed that men presenting with benign prostate enlargement or prostate cancer had higher blood estrogen levels (and often low free testosterone blood levels).(13-16) Subsequent clinical studies help confirm our early observations.(17-21)

Insufficient estrogen, on the other hand, predisposes men to osteoporosis and bone fracture.(22,23)

The fact that 99% of men today have no idea what their blood estrogen levels are helps explain the epidemic of age-related disease that is bankrupting this nation’s medical system.

New Study Published in the Journal of the American Medical Association

Conventional doctors tend to ignore hard science until it appears in their own medical journals.

A study published in the Journal of the American Medical Association (JAMA) measured blood estradiol (a dominant estrogen) in 501 men with chronic heart failure. Compared to men in the balanced estrogen quintile, men in the lowest estradiol quintile were 317% more likely to die during a 3-year follow-up, while men in the highest estradiol quintile were 133% more likely to die.(24)

The men in the balanced quintile—with the fewest deaths—had serum estradiol levels between 21.80 and 30.11 pg/mL. This is virtually the ideal range that we have long recommended males strive for.

The men in the highest quintile who suffered 133% increased death rates had serum estradiol levels of 37.40 pg/mL or above. The lowest estradiol group that suffered a 317% increased death rate had serum estradiol levels under 12.90 pg/mL.

The dramatic increase in mortality in men with unbalanced estrogen (i.e., estradiol levels either too high or too low) is nothing short of astounding. It uncovers a gaping hole in conventional cardiology practice that is easily correctable.

This study revealing the lethal dangers of estrogen imbalance was published in conventional medicine’s Bastille of knowledge—the Journal of the American Medical Association. Physicians no longer have a basis to question males who take aggressive approaches to maintain their serum estradiol levels in optimal ranges.

Low Estradiol and Testosterone Predict Mortality in Aging Men

Sales of testosterone replacement drugs have surged more than 20-fold in response to studies linking low testosterone to a host of common maladies.

In a recent study of 3,014 men aged 69-80 years, serum levels of testosterone and estradiol were measured during a mean follow-up of 4.5 years. Men with low testosterone had 65% greater all-cause mortality, while men with low estradiol suffered 54% more deaths.(25)

Those men low in estradiol and testosterone were almost twice as likely to die (a 96% increase in mortality) compared to men in the optimal ranges.(25)

This large study of aged men corroborates prior published reports linking imbalances of testosterone and/or estradiol with greater incidences of degenerative disease and death.(26-36)

How Do Men Naturally Make Estrogen?

Women synthesize most of their estrogen in their ovaries and other reproductive tissues.

Since men lack this female anatomy, they need to produce estrogen through a process involving an enzyme called aromatase that transforms testosterone into estradiol.

Aging men sometimes have too much aromatase activity, which causes their testosterone to convert to excess estradiol. This results in depletion of vital testosterone while spiking estradiol to unsafe ranges.

Some men lack aromatase and suffer an estrogen deficit. Other men produce so little endogenous testosterone that there is not enough to convert into estrogen, which causes low levels of both free testosterone and estradiol.

Fortunately, no matter what the underlying cause, aging men can easily achieve optimal free testosterone and estradiol serum levels.

Free testosterone is the unbound form that is biologically available to cell receptor sites throughout the body. Measuring free testosterone blood levels is the most accurate way of assessing testosterone status in aging men.

How Aging Men Can Control Their Estrogen Levels

An epidemic problem observed in aging males is insufficient free testosterone, i.e., less than 15-20 pg/mL of serum. When accompanied by excess estradiol (over 30 pg/mL of serum), this can signal excess aromatase enzyme activity.

Excess aromatase robs men of their testosterone while exposing them to higher than desirable estradiol.(37) Aromatase can be suppressed with absorbable forms of chrysin (a plant flavonoid) and/or lignans such as those extracted from the Norway spruce tree (HMRlignan™).(38-42)

If these nutrients fail to reduce estradiol adequately, then we suggest that men ask their doctor to prescribe an aromatase-inhibiting drug like Arimidex® in the very low dose of 0.5 mg twice a week.

When aromatase is properly suppressed, estradiol levels are reduced to safe ranges, while free testosterone often increases, since less testosterone is being aromatized into estradiol.

Why Some Men Need Topical Testosterone Creams

Most testosterone in a man’s body emanates from the testes. Aging results in a decline in testicular output, thus necessitating the topical application of a testosterone cream to restore this vital hormone to youthful levels. Ideal free serum testosterone levels for most aging men are between 20-25 pg/mL.

As you may surmise, a man who produces too little testosterone risks a lethal deficiency of both free testosterone and estradiol. That’s because men need testosterone to synthesize estradiol in their bodies. In the presence of insufficient testosterone production, some aging men are vulnerable to low free testosterone and low estradiol that according to the latest study almost doubles their risk of dying over a 4.5 year period!(25)

Critical Importance of Blood Testing

Today’s conventional physicians prescribe blood tests to check glucose, cholesterol, and triglycerides, but rarely check their male patients’ free testosterone and estradiol levels.

When looking at the horrific-ally high mortality rates associated with imbalances of these critical hormones, it becomes strikingly apparent that a significant number of heart attacks, strokes, bone fractures, and other degenerative diseases are easily preventable.

One reason these hormone blood tests are not normally prescribed is their high retail cost, and the fact that many insurance companies refuse to pay for them.

As a client of The Health & Rejuvenation Center, you don’t have to be victimized by conventional medical ignorance, high prices, or insurance company indifference.

Take Charge of Your Health with Low-Cost Blood Testing

An all-inclusive blood test panel that includes free testosterone and estradiol can retail for $1,000 at commercial labs. The same test can be acquire through The Health & Rejuvenation Center for a fraction of the price.

If your blood test result reveals an imbalance of free testosterone and/or estradiol, you are in a position to initiate immediate corrective action. Not only can restoring youthful hormone balance save your life, but men (and women) often experience an enhancement in their quality of life after their hormones are adjusted to optimal ranges.

A complete description of the Male and Female Blood Test Panels can be found on this site. As you’ll readily see, these panels contain many important tests (such as homocysteine, C-reactive protein, and DHEA) that mainstream doctors seldom check for.

To order a comprehensive Male and/or Female Blood Test Panel, just call 1-800-466-2209. It is the single most important step you can take to ensure your continued good health.

REFERENCES

1.Suzuki K, Ito K, Ichinose Y, Kurokawa K, Suzuki T. Endocrine environment of benign prostatic hyperplasia prostate size and volume are correlated with serum estrogen concentration. Scand J Urol Nephrol. 1995 Mar;29(1):65-8.

2.Lindholm J, Eldrup E, Winkel P. Variability in plasma oestrogen concentrations in men with a myocardial Infarction. Dan Med Bull. 1990 Dec;37(6):552-6.

3.Usuki F, Nakazato O, Osame M, Igata A. Hyperestrogenemia in neuromuscular diseases. J Neurol Sci. 1989 Feb;89(2-3):189-97.

4.Zumoff B. Hormonal abnormalities in obesity. Acta Med Scand Suppl. 1988; 723:153-60.

5.Small M, MacRury S, Beastall GH. Oestradiol levels in diabetic men with and without a previous myocardial infarction. Q J Med. 1987 Jul;64(243):617-23.

6.Phillips GB. Evidence for hyperestrogenemia as the link between diabetes mellitus and myocardial infarction. Am J Med. 1984 Jun;76(6):1041-8.

7.Klaiber EL, Broverman DM, Haffajee CI, Hochman JS, Sacks GM, Dalen JE. Serum estrogen levels in men with acute myocardial infarction. Am J Med. 1982 Dec;73(6):872-81.

8.Jeppesen LL, Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS, Winther K. Decreased serum testosterone in men with acute ischemic stroke. Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):749-54.

9.Phillips GB, Pinkernell BH, Jing TY. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb. 1994 May;14(5):701-6.

10.Abbott RD, Launer LJ, Rodriguez BL, et al. Serum estradiol and risk of stroke in elderly men. Neurology. 2007 Feb 20;68(8):563-8.

11.Dunajska K, Milewicz A, Szymczak J, et al. Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis. Aging Male. 2004 Sep;7(3):197-204.

12.Wranicz JK, Cygankiewicz I, Rosiak M, Kula P, Kareba W. The relationship between sex hormones and lipid profile in men with coronary artery disease. Int J Cardiol. 2005 May 11;101(1):105-10.

13.Krieg M, Nass R, Tunn S. Effect of aging on endogenous level of 5 alpha-dihydrotestosterone, testosterone, estradiol, and estrone in epithelium and stroma of normal and hyperplastic human prostate. J Clin Endocrinol Metab. 1993 Aug;77(2):375-81.

14.Gann PH, Hennekens CH, Longcope C, Verhoek-Oftedahl W, Grodstein F, Stampfer MJ. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. Prostate. 1995 Jan;26(1):40-9.

15.Shibata Y, Ito K, Suzuki K, et al. Changes in the endocrine environment of the human prostate transition zone with aging: simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate. 2000 Jan;42(1):45-55.

16.Prins GS, Huang L, Birch L, Pu Y. The role of estrogens in normal and abnormal development of the prostate gland. Ann N Y Acad Sci. 2006 Nov;1089:1-13.

17.Prins GS, Korach KS. The role of estrogens and estrogen receptors in normal prostate growth and disease. Steroids. 2008 Mar;73(3):233-44.

18.Matsuda T, Abe H, Suda K. Relation between benign prostatic hyperplasia and obesity and estrogen. Rinsho Byori. 2004 Apr;52(4):291-4.

19.Ho CK, Nanda J, Chapman KE, Habib FK. Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen. J Endocrinol. 2008 Jun;197(3):483-91.

20.Singh PB, Matanhelia SS, Martin FL. A potential paradox in prostate adenocarcinoma progression: oestrogen as the initiating driver. Eur J Cancer. 2008 May;44(7):928-36.

21.Giton F, de la Taille A, Allory Y, et al. Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa). J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):158-67.

22.Mellström D, Vandenput L, Mallmin H, et al. Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res. 2008 Oct;23(10):1552-60.

23.Pernow Y, Hauge EM, Linder K, Dahl E, Sääf M. Bone histomorphometry in male idiopathic osteoporosis. Calcif Tissue Int. 2009 Jun;84(6):430-8.

24.Jankowska EA, Rozentryt P, Ponikowska B. Circulating estradiol and mortality in men with systolic chronic heart failure. JAMA. 2009 May 13;301(18):1892-901.

25.Tivesten A, Vandenput L, Labrie F, et al. Low serum testosterone and estradiol predict mortality in elderly men. J Clin Endocrinol Metab. 2009 Jul;94(7):2482-8.

26.Tang YJ, Lee WJ, Chen YT, et al. Serum testosterone level and related metabolic factors in men over 70 years old. J Endocrinol Invest. 2007 Jun;30(6):451-8.

27.Laaksonen DE, Niskanen L, Punnonen K, et al. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003 Dec;149(6):601-8.

28.Cutolo M, Seriolo B, Villaggio B, Pizzorni C, Craviotto C, Sulli A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann NY Acad Sci. 2002 Jun;966:131-42.

29.Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab. 2002 Nov;87(11):5001-7.

30.Hogervorst E, Combrinck M, Smith AD. Testosterone and gonadotropin levels in men with dementia. Neuro Endocrinol Lett. 2003 Jun;24(3-4):203-8.

31.Gouras GK, Xu H, Gross RS, et al. Testosterone reduces neuronal secretion of Alzheimer’s beta-amyloid peptides. Proc Natl Acad Sci USA. 2000 Feb 1;97(3):1202-5.

32.Traish AM, Saad F, Guay A. The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance. J Androl. 2009 Jan-Feb;30(1):23-32.

33.Khaw KT, Dowsett M, Folkerd E, et al. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation. 2007 Dec 4;116(23):2694-701.

34.Debing E, Peeters E, Duquet W, Poppe K, Velkeniers B, Van Den Branden P. Men with atherosclerotic stenosis of the carotid artery have lower testosterone levels compared with controls. Int Angiol. 2008 Apr;27(2):135-41.

35.Muller M, van den Beld AW, Bots ML, Grobbee DE, Lamberts SW, van der Schouw YT. Endogenous sex hormones and progression of carotid atherosclerosis in elderly men. Circulation. 2004 May 4;109(17):2074-9.

36.Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab. 2002 Aug;87(8):3632-9.

37.Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C. Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. J Clin Endocrinol Metab. 2004 Mar;89(3):1174-80.

38.Ta N, Walle T. Aromatase inhibition by bioavailable methylated flavones. J Steroid Biochem Mol Biol. 2007 Oct;107(1-2):127-9.

39.Campbell DR, Kurzer MS. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.

40.Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984 Sep 7;225(4666):1032-4.

41.Saarinen NM, Warri A, Makela SI, et al. Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies). Nutr Cancer. 2000; 36(2):207-16.

42.Wang C, Makela T, Hase T, Adlercreutz H, Kurzer MS. Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12.

“The Greatest Health of Your Life”℠
National Testosterone Restoration for Men
Wellness & Preventative Medicine
Boston Testosterone Partners
www.BostonTestosterone.com
www.facebook.com/BostonTestosterone
855-617-MEDS (6337)/781-269-5953

cblaisdell@corenewengland.com

BTP/CORE New England
Men’s Health Centers
920 Washington Street
Norwood, MA 02062
www.BostonTestosterone.com
781.269.5953

Studies over and over show that low hormones are deleterious to ones health. When levels are off, one strives to correct the same. If cholesterol levels are high, you lower. If thyroid levels are high or low, you correct them. And, likewise, if hormones levels are off, you balance and optimize them.

This study shows that men aged 20–79 who have low testosterone levels below 8.7 nmol/L (250 ng/dL) have a more than two-fold increased risk of mortality from all causes, compared with those with higher serum testosterone levels. This risk is independent of age, waist circumference, smoking habits, high-risk alcohol use, and physical activity.

Background

The association of low serum testosterone levels with mortality has gained strength in recent research. However, there are few population-based studies on this association.
Objective
This study examined whether low serum testosterone levels are a risk factor for all-cause or cause-specific mortality in a population-based sample of men aged 20–79.

Methods

We used data from 1954 men recruited for the prospective population-based Study of Health in Pomerania, with measured serum testosterone levels at baseline and 195 deaths during an average 7.2-year follow-up.

A total serum testosterone level of less than 8.7 nmol/L (250 ng/dL) was classified as low.

The relationships of low serum testosterone levels with all-cause and cause-specific mortality were analysed by Cox proportional hazards regression models.

Results

Men with low serum testosterone levels had a significantly higher mortality from all causes than men with higher serum testosterone levels (HR 2.24; 95% CI 1.41–3.57).

After adjusting for waist circumference, smoking habits, high-risk alcohol use, physical activity, renal insufficiency, and levels of dehydroepiandrosterone sulfate (DHEAS), low serum testosterone levels continued to be associated with increased mortality (HR 2.32; 95% CI 1.38–3.89).

In cause-specific analyses, low serum testosterone levels predicted increased risk of death from cardiovascular disease (CVD) (HR 2.56; 95% CI 1.15–6.52) and cancer (HR 3.46; 95% CI 1.68–6.68), but not from respiratory diseases or other causes.

Conclusion

Low serum testosterone levels were associated with an increased risk of all-cause mortality independent of numerous risk factors. As serum testosterone levels are inversely related to mortality due to CVD and cancer, it may be used as a predictive marker to improve the ability to predict health risks.

Reference:
Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79.
Haring R, Völzke H, Steveling A, Krebs A, Felix SB, Schöfl C, Dörr M, Nauck M, Wallaschofski H.
Eur Heart J. 2010 Jun;31(12):1494-501

http://www.ncbi.nlm.nih.gov/pubmed/20164245

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